HIV-1 gp160 induces transforming growth factor-β production in human PBMC
R Hu, N Oyaizu, S Than, VS Kalyanaraman… - Clinical immunology and …, 1996 - Elsevier
Transforming growth factor-β (TGF-β) is a multifunctional cytokine secreted by many
mononuclear cells in peripheral blood (PBMC) and has diverse effects on cellular and
humoral immunity. Increased TGF-β mRNA expression has been reported in PBMC of HIV-
infected patients, but the mechanism by which HIV induces TGF-β secretion is unknown. In
this study, we observed that HIV gp160 could induce significant TGF-β secretion and TGF-β
mRNA expression in PBMC from HIV-seronegative healthy donors. The cellular source of …
mononuclear cells in peripheral blood (PBMC) and has diverse effects on cellular and
humoral immunity. Increased TGF-β mRNA expression has been reported in PBMC of HIV-
infected patients, but the mechanism by which HIV induces TGF-β secretion is unknown. In
this study, we observed that HIV gp160 could induce significant TGF-β secretion and TGF-β
mRNA expression in PBMC from HIV-seronegative healthy donors. The cellular source of …
