Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain
tolerance via the regulation of lymphocyte proliferation, differentiation, and survival. In
addition, TGF-β controls the initiation and resolution of inflammatory responses through the
regulation of chemotaxis, activation, and survival of lymphocytes, natural killer cells,
dendritic cells, macrophages, mast cells, and granulocytes. The regulatory activity of TGF-β …