A human REV7 homolog that interacts with the polymerase ζ catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2
Y Murakumo, T Roth, H Ishii, D Rasio, S Numata… - Journal of Biological …, 2000 - jbc.org
Widespread alteration of the genomic DNA is a hallmark of tumors, and alteration of genes
involved in DNA maintenance have been shown to contribute to the tumorigenic process.
The DNA polymerase ζ of Saccharomyces cerevisiae is required for error-prone repair
following DNA damage and consists of a complex between three proteins, scRev1, scRev3,
and scRev7. Here we describe a candidate human homolog of S. cerevisiae Rev7 (hREV7),
which was identified in a yeast two-hybrid screen using the human homolog of S. cerevisiae …
involved in DNA maintenance have been shown to contribute to the tumorigenic process.
The DNA polymerase ζ of Saccharomyces cerevisiae is required for error-prone repair
following DNA damage and consists of a complex between three proteins, scRev1, scRev3,
and scRev7. Here we describe a candidate human homolog of S. cerevisiae Rev7 (hREV7),
which was identified in a yeast two-hybrid screen using the human homolog of S. cerevisiae …
