Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor
JH Kim, JH Shin, IH Kim - … Journal of Radiation Oncology* Biology* Physics, 2004 - Elsevier
PURPOSE: Histone deacetylase inhibitors (HDAC-Is) show in vitro and in vivo antitumor
activity in various types of cancer cells and are being studied in clinical trials. However,
studies addressing the combination of HDAC-I and radiation are lacking. The purpose of this
study was to assess the effect of trichostatin A (TSA), an HDAC-I, on the radiosensitivity of
U373MG and U87MG (human glioblastoma) cell lines. METHODS AND MATERIALS:
Intrinsic TSA toxicity was determined by measuring survival in exponentially growing cells …
activity in various types of cancer cells and are being studied in clinical trials. However,
studies addressing the combination of HDAC-I and radiation are lacking. The purpose of this
study was to assess the effect of trichostatin A (TSA), an HDAC-I, on the radiosensitivity of
U373MG and U87MG (human glioblastoma) cell lines. METHODS AND MATERIALS:
Intrinsic TSA toxicity was determined by measuring survival in exponentially growing cells …
