Genetic analysis of association between calcium signaling and hippocampal activation, memory performance in the young and old, and risk for sporadic Alzheimer …
A Heck, M Fastenrath, D Coynel, B Auschra… - JAMA …, 2015 - jamanetwork.com
Importance Human episodic memory performance is linked to the function of specific brain
regions, including the hippocampus; declines as a result of increasing age; and is markedly
disturbed in Alzheimer disease (AD), an age-associated neurodegenerative disorder that
primarily affects the hippocampus. Exploring the molecular underpinnings of human
episodic memory is key to the understanding of hippocampus-dependent cognitive
physiology and pathophysiology. Objective To determine whether biologically defined …
regions, including the hippocampus; declines as a result of increasing age; and is markedly
disturbed in Alzheimer disease (AD), an age-associated neurodegenerative disorder that
primarily affects the hippocampus. Exploring the molecular underpinnings of human
episodic memory is key to the understanding of hippocampus-dependent cognitive
physiology and pathophysiology. Objective To determine whether biologically defined …
