Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury
M Malet, C Leiguarda, G Gastón, C McCarthy… - Peptides, 2017 - Elsevier
Neuropeptide tyrosine (NPY) and its associated receptors Y1R and Y2R have been
previously implicated in the spinal modulation of neuropathic pain induced by total or partial
sectioning of the sciatic nerve. However, their role in chronic constrictive injuries of the
sciatic nerve has not yet been described. In the present study, we analyzed the
consequences of pharmacological activation of spinal Y1R, by using the specific Y1R
agonist Leu 31 Pro 34-NPY, in rats with chronic constriction injury (CCI). CCI and sham …
previously implicated in the spinal modulation of neuropathic pain induced by total or partial
sectioning of the sciatic nerve. However, their role in chronic constrictive injuries of the
sciatic nerve has not yet been described. In the present study, we analyzed the
consequences of pharmacological activation of spinal Y1R, by using the specific Y1R
agonist Leu 31 Pro 34-NPY, in rats with chronic constriction injury (CCI). CCI and sham …
