Our previous work indicates that the intrathecal administration of neuropeptide Y (NPY) acts
at its cognate receptors to reduce behavioral signs of nociception in several models of
inflammatory pain, including the formalin test. The present study extends these findings to a
rat model of peripheral neuropathic pain, and then evaluates the hypothesis that NPY
inhibits inflammation-and nerve injury-induced activation of spinal nociceptive transmission.
Here we show that NPY dose-dependently reduced behavioral signs of mechanical and …