Synaptic dynamics of the feed-forward inhibitory circuitry gating mechanical allodynia in mice
Q Wang, X Zhang, X He, S Du, Z Jiang, P Liu, L Qi… - …, 2020 - pubs.asahq.org
Background The authors' previous studies have found that spinal protein kinase C γ
expressing neurons are involved in the feed-forward inhibitory circuit gating mechanical
allodynia in the superficial dorsal horn. The authors hypothesize that nerve injury enhances
the excitability of spinal protein kinase C γ expressing interneurons due to disinhibition of
the feed-forward inhibitory circuit, and enables Aβ primary inputs to activate spinal protein
kinase C γ expressing interneurons. Methods Prkcg-P2A-tdTomato mice were constructed …
expressing neurons are involved in the feed-forward inhibitory circuit gating mechanical
allodynia in the superficial dorsal horn. The authors hypothesize that nerve injury enhances
the excitability of spinal protein kinase C γ expressing interneurons due to disinhibition of
the feed-forward inhibitory circuit, and enables Aβ primary inputs to activate spinal protein
kinase C γ expressing interneurons. Methods Prkcg-P2A-tdTomato mice were constructed …
