Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian
selection. Genes from various signalling pathways such as telomere maintenance, Wnt/β-
catenin, P53/cell cycle regulation, oxidative stress, epigenetic modifiers, AKT/mTOR and
MAP kinase are frequently mutated in HCC. Several subclasses of HCC have been
identified based on transcriptomic dysregulation and genetic alterations that are closely …