[HTML][HTML] Attempting to compensate for reduced neuronal nitric oxide synthase protein with nitrate supplementation cannot overcome metabolic dysfunction but rather …
Duchenne muscular dystrophy arises from the loss of dystrophin and is characterized by
calcium dysregulation, muscular atrophy, and metabolic dysfunction. The secondary
reduction of neuronal nitric oxide synthase (nNOS) from the sarcolemma reduces NO
production and bioavailability. As NO modulates glucose uptake, metabolism, and
mitochondrial bioenergetics, we investigated whether an 8-week nitrate supplementation
regimen could overcome metabolic dysfunction in the mdx mouse. Dystrophin-positive …
calcium dysregulation, muscular atrophy, and metabolic dysfunction. The secondary
reduction of neuronal nitric oxide synthase (nNOS) from the sarcolemma reduces NO
production and bioavailability. As NO modulates glucose uptake, metabolism, and
mitochondrial bioenergetics, we investigated whether an 8-week nitrate supplementation
regimen could overcome metabolic dysfunction in the mdx mouse. Dystrophin-positive …
