Pre-clinical screening of drugs using the mdx mouse
JA Granchelli, C Pollina, MS Hudecki - Neuromuscular Disorders, 2000 - Elsevier
The genetically dystrophin-deficient mdx mouse, with its characteristic and regular exercise-
induced loss of strength, is a useful experimental platform on which to screen potential drug
therapies in the treatment of some dystrophic diseases. Pharmacological agents of several
chemical and functional classes were examined in their ability to reduce the loss of muscular
strength in young exercised mdx mice. Therapeutic intervention over the period 4–10 weeks
of age was evaluated in weekly tests of whole-body strength. This age period represents the …
induced loss of strength, is a useful experimental platform on which to screen potential drug
therapies in the treatment of some dystrophic diseases. Pharmacological agents of several
chemical and functional classes were examined in their ability to reduce the loss of muscular
strength in young exercised mdx mice. Therapeutic intervention over the period 4–10 weeks
of age was evaluated in weekly tests of whole-body strength. This age period represents the …