[HTML][HTML] Revisiting the dystrophin-ATP connection: How half a century of research still implicates mitochondrial dysfunction in Duchenne Muscular Dystrophy aetiology
Abstract Duchenne Muscular Dystrophy (DMD) is a fatal neuromuscular disease that is
characterised by dystrophin-deficiency and chronic Ca 2+-induced skeletal muscle wasting,
which currently has no cure. DMD was once considered predominantly as a metabolic
disease due to the myriad of metabolic insufficiencies evident in the musculature, however
this aspect of the disease has been extensively ignored since the discovery of dystrophin.
The collective historical and contemporary literature documenting these metabolic nuances …
characterised by dystrophin-deficiency and chronic Ca 2+-induced skeletal muscle wasting,
which currently has no cure. DMD was once considered predominantly as a metabolic
disease due to the myriad of metabolic insufficiencies evident in the musculature, however
this aspect of the disease has been extensively ignored since the discovery of dystrophin.
The collective historical and contemporary literature documenting these metabolic nuances …
