[HTML][HTML] Curcumin alleviates dystrophic muscle pathology in mdx mice
Y Pan, C Chen, Y Shen, CH Zhu, G Wang, XC Wang… - Molecules and cells, 2008 - Elsevier
Abnormal activation of nuclear factor kappa B (NF-κB) probably plays an important role in
the pathogenesis of Duchenne's muscular dystrophy (DMD). In this report, we evaluated the
efficacy of curcumin, a potent NF-κB inhibitor, in mdx mice, a mouse model of DMD. We
found that it improved sarcolemmic integrity and enhanced muscle strength after
intraperitoneal (ip) injection. Histological analysis revealed that the structural defects of
myofibrils were reduced, and biochemical analysis showed that creatine kinase (CK) activity …
the pathogenesis of Duchenne's muscular dystrophy (DMD). In this report, we evaluated the
efficacy of curcumin, a potent NF-κB inhibitor, in mdx mice, a mouse model of DMD. We
found that it improved sarcolemmic integrity and enhanced muscle strength after
intraperitoneal (ip) injection. Histological analysis revealed that the structural defects of
myofibrils were reduced, and biochemical analysis showed that creatine kinase (CK) activity …
