[HTML][HTML] Ketone bodies, stress response, and redox homeostasis
P Rojas-Morales, J Pedraza-Chaverri, E Tapia - Redox Biology, 2020 - Elsevier
P Rojas-Morales, J Pedraza-Chaverri, E Tapia
Redox Biology, 2020•ElsevierThe ketone body β-hydroxybutyrate is no longer viewed simply as a metabolic intermediate,
as it regulates a broad range of physiological processes at cellular and systemic levels.
Particularly, β-hydroxybutyrate functions as a stress response molecule and orchestrates an
antioxidant defense program to maintain redox homeostasis in response to environmental
and metabolic challenges, such as ischemia. This property of β-hydroxybutyrate might be
key for the beneficial effect of calorie restriction on stress response and disease processes.
as it regulates a broad range of physiological processes at cellular and systemic levels.
Particularly, β-hydroxybutyrate functions as a stress response molecule and orchestrates an
antioxidant defense program to maintain redox homeostasis in response to environmental
and metabolic challenges, such as ischemia. This property of β-hydroxybutyrate might be
key for the beneficial effect of calorie restriction on stress response and disease processes.
Abstract
The ketone body β-hydroxybutyrate is no longer viewed simply as a metabolic intermediate, as it regulates a broad range of physiological processes at cellular and systemic levels. Particularly, β-hydroxybutyrate functions as a stress response molecule and orchestrates an antioxidant defense program to maintain redox homeostasis in response to environmental and metabolic challenges, such as ischemia. This property of β-hydroxybutyrate might be key for the beneficial effect of calorie restriction on stress response and disease processes.
Elsevier