RNA polymerase III as a gatekeeper to prevent severe VZV infections
ME Carter-Timofte, SR Paludan… - Trends in Molecular …, 2018 - cell.com
Trends in Molecular Medicine, 2018•cell.com
In most individuals, varicella zoster virus (VZV) causes varicella upon primary infection and
zoster during reactivation. However, in a subset of individuals, VZV may cause severe
disease, including encephalitis. Host genetics is believed to be the main determinant of
exacerbated disease manifestations. Recent studies have demonstrated that defects in the
DNA sensor RNA polymerase III (POL III) confer selective increased susceptibility to VZV
infection, thus providing fundamental new insight into VZV immunity. Here we describe the …
zoster during reactivation. However, in a subset of individuals, VZV may cause severe
disease, including encephalitis. Host genetics is believed to be the main determinant of
exacerbated disease manifestations. Recent studies have demonstrated that defects in the
DNA sensor RNA polymerase III (POL III) confer selective increased susceptibility to VZV
infection, thus providing fundamental new insight into VZV immunity. Here we describe the …
In most individuals, varicella zoster virus (VZV) causes varicella upon primary infection and zoster during reactivation. However, in a subset of individuals, VZV may cause severe disease, including encephalitis. Host genetics is believed to be the main determinant of exacerbated disease manifestations. Recent studies have demonstrated that defects in the DNA sensor RNA polymerase III (POL III) confer selective increased susceptibility to VZV infection, thus providing fundamental new insight into VZV immunity. Here we describe the roles of POL III in housekeeping and immune surveillance during VZV infection. We present the latest knowledge on the role of POL III in VZV infection and discuss outstanding questions related to the role of POL III in VZV immunity, and how this insight can be translated into clinical medicine.
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