Vascular endothelial growth factor promotes physical wound repair and is anti-apoptotic in primary distal lung epithelial and A549 cells
JR Roberts, GD Perkins, T Fujisawa… - Critical care …, 2007 - journals.lww.com
Objective: There is evidence to suggest a beneficial role for growth factors, including
vascular endothelial growth factor (VEGF), in tissue repair and proliferation after injury within
the lung. Whether this effect is mediated predominantly by actions on endothelial cells or
epithelial cells is unknown. This study tested the hypothesis that VEGF acts as an autocrine
trophic factor for human adult alveolar epithelial cells and that under situations of pro-
apoptotic stress, VEGF reduces cell death. Design: In vitro cell culture study looking at the …
vascular endothelial growth factor (VEGF), in tissue repair and proliferation after injury within
the lung. Whether this effect is mediated predominantly by actions on endothelial cells or
epithelial cells is unknown. This study tested the hypothesis that VEGF acts as an autocrine
trophic factor for human adult alveolar epithelial cells and that under situations of pro-
apoptotic stress, VEGF reduces cell death. Design: In vitro cell culture study looking at the …