Synaptic plasticity, neuronal replay, and cross-regional communication are considered key
physiological processes underlying memory consolidation. Both cellular and systems-level
consolidation hypotheses are supported by extensive empirical evidence. However,
presently, little is known about the temporal relations between local synaptic modifications
and activity dynamics within extended neuronal networks supporting memory. The diffuse
ascending neuromodulatory systems, with the locus coeruleus (LC) noradrenergic system …