Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model
ZMN Quezado, S Kamimura, M Smith, X Wang… - Blood Cells, Molecules …, 2022 - Elsevier
Polymerization of deoxygenated sickle hemoglobin (HbS) leads to erythrocyte sickling.
Enhancing activity of the erythrocyte glycolytic pathway has anti-sickling potential as this
reduces 2, 3-diphosphoglycerate (2, 3-DPG) and increases ATP, factors that decrease HbS
polymerization and improve erythrocyte membrane integrity. These factors can be
modulated by mitapivat, which activates erythrocyte pyruvate kinase (PKR) and improves
sickling kinetics in SCD patients. We investigated mechanisms by which mitapivat may …
Enhancing activity of the erythrocyte glycolytic pathway has anti-sickling potential as this
reduces 2, 3-diphosphoglycerate (2, 3-DPG) and increases ATP, factors that decrease HbS
polymerization and improve erythrocyte membrane integrity. These factors can be
modulated by mitapivat, which activates erythrocyte pyruvate kinase (PKR) and improves
sickling kinetics in SCD patients. We investigated mechanisms by which mitapivat may …