[HTML][HTML] Assembling an actin cytoskeleton for cell attachment and movement

JV Small, K Rottner, I Kaverina, KI Anderson - Biochimica Et Biophysica …, 1998 - Elsevier
Biochimica Et Biophysica Acta (BBA)-Molecular Cell Research, 1998Elsevier
The crawling movements of metazoan cells result from coordinated and polarised changes
in cell shape, orchestrated via a continuous remodelling of the actin cytoskeleton. The
signalling pathways that lead to remodelling involve the rho-family of small GTPases [27, 52,
56, 70, 72] whose individual members induce the expression of different actin¢ lament
subcompartments, generally categorised as lamellipodia,¢ lopodia, stress¢ bres and arcs
([32, 61]; Fig. 1). Depending on the cell type and conditions, the relative expression of these …
The crawling movements of metazoan cells result from coordinated and polarised changes in cell shape, orchestrated via a continuous remodelling of the actin cytoskeleton. The signalling pathways that lead to remodelling involve the rho-family of small GTPases [27, 52, 56, 70, 72] whose individual members induce the expression of different actin¢ lament subcompartments, generally categorised as lamellipodia,¢ lopodia, stress¢ bres and arcs ([32, 61]; Fig. 1). Depending on the cell type and conditions, the relative expression of these different actin¢ lament assemblies
0167-4889/98/$^ see front matter ß 1998 Elsevier Science BV All rights reserved. PII: S 0 1 6 7-4 8 8 9 (9 8) 0 0 0 8 0-9
Elsevier