Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/β-catenin/Tcf pathway
M Joo, A Shahsafaei, RD Odze - Human pathology, 2009 - Elsevier
Paneth cell differentiation may occur in colonic epithelial neoplasms. However, its
significance and mechanism of development remains unclear. Human defensin 5 is a
specific marker of Paneth cells and has been shown to represent one of the target genes of
the Apc/β-catenin/Tcf pathway. The aim of this study was to evaluate the frequency of Paneth
cell differentiation in a variety of colonic neoplasms, and to investigate the role of human
defensin 5 and β-catenin in this process. The clinical and pathologic findings, including …
significance and mechanism of development remains unclear. Human defensin 5 is a
specific marker of Paneth cells and has been shown to represent one of the target genes of
the Apc/β-catenin/Tcf pathway. The aim of this study was to evaluate the frequency of Paneth
cell differentiation in a variety of colonic neoplasms, and to investigate the role of human
defensin 5 and β-catenin in this process. The clinical and pathologic findings, including …
