Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder
MA Mergy, R Gowrishankar, GL Davis… - Neurochemistry …, 2014 - Elsevier
Alterations in dopamine (DA) signaling underlie the most widely held theories of molecular
and circuit level perturbations that lead to risk for attention-deficit hyperactivity disorder
(ADHD). The DA transporter (DAT), a presynaptic reuptake protein whose activity provides
critical support for DA signaling by limiting DA action at pre-and postsynaptic receptors, has
been consistently associated with ADHD through pharmacological, behavioral, brain
imaging and genetic studies. Currently, the animal models of ADHD exhibit significant …
and circuit level perturbations that lead to risk for attention-deficit hyperactivity disorder
(ADHD). The DA transporter (DAT), a presynaptic reuptake protein whose activity provides
critical support for DA signaling by limiting DA action at pre-and postsynaptic receptors, has
been consistently associated with ADHD through pharmacological, behavioral, brain
imaging and genetic studies. Currently, the animal models of ADHD exhibit significant …
