The L-type calcium channel Cav1. 3 is required for proper hippocampal neurogenesis and cognitive functions
J Marschallinger, A Sah, C Schmuckermair, M Unger… - Cell Calcium, 2015 - Elsevier
L-type voltage gated Ca 2+ channels (LTCCs) are widely expressed within different brain
regions including the hippocampus. The isoforms Cav1. 2 and Cav1. 3 have been shown to
be involved in hippocampus-dependent learning and memory, cognitive functions that
require proper hippocampal neurogenesis. In vitro, functional LTCCs are expressed on
neuronal progenitor cells, where they promote neuronal differentiation. Expression of LTCCs
on neural stem and progenitor cells within the neurogenic regions in the adult brain in vivo …
regions including the hippocampus. The isoforms Cav1. 2 and Cav1. 3 have been shown to
be involved in hippocampus-dependent learning and memory, cognitive functions that
require proper hippocampal neurogenesis. In vitro, functional LTCCs are expressed on
neuronal progenitor cells, where they promote neuronal differentiation. Expression of LTCCs
on neural stem and progenitor cells within the neurogenic regions in the adult brain in vivo …
