L-type calcium channels in adrenal chromaffin cells: role in pace-making and secretion
A Marcantoni, P Baldelli, JM Hernandez-Guijo… - Cell calcium, 2007 - Elsevier
Voltage-gated L-type (Cav1. 2 and Cav1. 3) channels are widely expressed in
cardiovascular tissues and represent the critical drug-target for the treatment of several
cardiovascular diseases. The two isoforms are also abundantly expressed in neuronal and
neuroendocrine tissues. In the brain, Cav1. 2 and Cav1. 3 channels control synaptic
plasticity, somatic activity, neuronal differentiation and brain aging. In neuroendocrine cells,
they are involved in the genesis of action potential generation, bursting activity and hormone …
cardiovascular tissues and represent the critical drug-target for the treatment of several
cardiovascular diseases. The two isoforms are also abundantly expressed in neuronal and
neuroendocrine tissues. In the brain, Cav1. 2 and Cav1. 3 channels control synaptic
plasticity, somatic activity, neuronal differentiation and brain aging. In neuroendocrine cells,
they are involved in the genesis of action potential generation, bursting activity and hormone …
