[HTML][HTML] Comparison of human monocyte derived macrophages and THP1-like macrophages as in vitro models for M. tuberculosis infection
Macrophages are the preferential cell types to study various aspects of mycobacterial
infection. Commonly used infection models for in-vitro studies are primary macrophages
such as human monocyte derived macrophages (hMDMs) and macrophage like cell lines
(THP-1). It is not clear if commercially available THP-1 cells can be used as hMDMs
alternative for in-vitro M. tb infection experiments. We conducted a detailed investigation of
the hMDM and THP-1 response to mycobacterial infection on a comparative basis and …
infection. Commonly used infection models for in-vitro studies are primary macrophages
such as human monocyte derived macrophages (hMDMs) and macrophage like cell lines
(THP-1). It is not clear if commercially available THP-1 cells can be used as hMDMs
alternative for in-vitro M. tb infection experiments. We conducted a detailed investigation of
the hMDM and THP-1 response to mycobacterial infection on a comparative basis and …
