Vascular-resident CD169-positive monocytes and macrophages control neutrophil accumulation in the kidney with ischemia-reperfusion injury
K Karasawa, K Asano, S Moriyama… - Journal of the …, 2015 - journals.lww.com
Monocytes and kidney-resident macrophages are considered to be involved in the
pathogenesis of renal ischemia-reperfusion injury (IRI). Several subsets of monocytes and
macrophages are localized in the injured tissue, but the pathologic roles of these cells are
not fully understood. Here, we show that CD169+ monocytes and macrophages have a
critical role in preventing excessive inflammation in IRI by downregulating intercellular
adhesion molecule-1 (ICAM-1) expression on vascular endothelial cells. Mice depleted of …
pathogenesis of renal ischemia-reperfusion injury (IRI). Several subsets of monocytes and
macrophages are localized in the injured tissue, but the pathologic roles of these cells are
not fully understood. Here, we show that CD169+ monocytes and macrophages have a
critical role in preventing excessive inflammation in IRI by downregulating intercellular
adhesion molecule-1 (ICAM-1) expression on vascular endothelial cells. Mice depleted of …