Rapamycin and 3-methyladenine regulate apoptosis and autophagy in bone-derived endothelial progenitor cells
F Lei, X Li, LIU Hui, R ZHU, Q MENG… - Chinese Medical …, 2012 - journals.lww.com
Background Mammalian target of rapamycin (mTOR) is involved in a caspase independent
form of programmed cell death called autophagy. The aim of this research was to investigate
the effects of rapamycin and 3-methyladenine (3-MA) on autophagy, proliferation, apoptosis,
and cell-cycle parameters of rat bone marrow-derived endothelial progenitor cells (EPCs).
Methods Mononuclear cells isolated from rat bone marrow were treated with rapamycin
(0.01, 0.1, 1, or 10 μg/L) or 3-MA (1.25, 2.5, 5, or 10 mmol/L) for 24 hours. Expression of the …
form of programmed cell death called autophagy. The aim of this research was to investigate
the effects of rapamycin and 3-methyladenine (3-MA) on autophagy, proliferation, apoptosis,
and cell-cycle parameters of rat bone marrow-derived endothelial progenitor cells (EPCs).
Methods Mononuclear cells isolated from rat bone marrow were treated with rapamycin
(0.01, 0.1, 1, or 10 μg/L) or 3-MA (1.25, 2.5, 5, or 10 mmol/L) for 24 hours. Expression of the …