Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention …

Å Hjalmarson, S Goldstein, B Fagerberg, H Wedel… - Jama, 2000 - jamanetwork.com
ContextResults from recent studies on the effects of β1-blockade in patients with heart failure
demonstrated a 34% reduction in total mortality. However, the effect of β1-blockade on the
frequency of hospitalizations, symptoms, and quality of life in patients with heart failure has
not been fully explored. ObjectiveTo examine the effects of the β1-blocker controlled-
release/extended-release metoprolol succinate (metoprolol CR/XL) on mortality,
hospitalization, symptoms, and quality of life in patients with heart failure …