[HTML][HTML] CCL2 disrupts the adherens junction: implications for neuroinflammation
TK Roberts, EA Eugenin, L Lopez, IA Romero… - Laboratory …, 2012 - Elsevier
Alterations to blood–brain barrier (BBB) adhesion molecules and junctional integrity during
neuroinflammation can promote central nervous system (CNS) pathology. The chemokine
CCL2 is elevated during CNS inflammation and is associated with endothelial dysfunction.
The effects of CCL2 on endothelial adherens junctions (AJs) have not been defined. We
demonstrate that CCL2 transiently induces Src-dependent disruption of human brain
microvascular endothelial AJ. β-Catenin is phosphorylated and traffics from the AJ to …
neuroinflammation can promote central nervous system (CNS) pathology. The chemokine
CCL2 is elevated during CNS inflammation and is associated with endothelial dysfunction.
The effects of CCL2 on endothelial adherens junctions (AJs) have not been defined. We
demonstrate that CCL2 transiently induces Src-dependent disruption of human brain
microvascular endothelial AJ. β-Catenin is phosphorylated and traffics from the AJ to …