[HTML][HTML] PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury
J Shi, J Yu, Y Zhang, L Wu, S Dong, L Wu, L Wu… - Laboratory …, 2019 - Elsevier
Sepsis-related acute lung injury (ALI) remains a major cause of mortality in critically ill
patients and lacks specific therapy. Mitochondrial dysfunction is involved in the progression
of septic lung injury. Mitochondrial dynamics, mitophagy, and biogenesis converge to
constitute the assiduous quality control of mitochondria (MQC). Heme oxygenase-1 (HO-1)
protects against sepsis-induced ALI through the modulation of mitochondrial dynamics.
However, the causal relationship between HO-1 and the general processes of MQC, and …
patients and lacks specific therapy. Mitochondrial dysfunction is involved in the progression
of septic lung injury. Mitochondrial dynamics, mitophagy, and biogenesis converge to
constitute the assiduous quality control of mitochondria (MQC). Heme oxygenase-1 (HO-1)
protects against sepsis-induced ALI through the modulation of mitochondrial dynamics.
However, the causal relationship between HO-1 and the general processes of MQC, and …