Advances in the understanding of nitric oxide as a biological mediator and a therapeutic tool
continue to accumulate at a rapid rate. This review provides an update on recent
developments pertinent to the role of nitric oxide in adult lung disease. After a brief review of
basic nitric oxide biochemistry and physiology, the evidence supporting the role of nitric
oxide in the regulation of vascular and airway tone in the normal lung is considered. Clinical
studies addressing the pathophysiological role of nitric oxide in pulmonary hypertension …