[HTML][HTML] Lipopolysaccharide (LPS)-mediated angiopoietin-2-dependent autocrine angiogenesis is regulated by NADPH oxidase 2 (Nox2) in human pulmonary …
H Menden, S Welak, S Cossette… - Journal of Biological …, 2015 - ASBMB
Sepsis-mediated endothelial Angiopoeitin-2 (Ang2) signaling may contribute to
microvascular remodeling in the developing lung. The mechanisms by which bacterial cell
wall components such as LPS mediate Ang2 signaling in human pulmonary microvascular
endothelial cells (HPMECs) remain understudied. In HPMEC, LPS-induced Ang2, Tie2, and
VEGF-A protein expression was preceded by increased superoxide formation. NADPH
oxidase 2 (Nox2) inhibition, but not Nox4 or Nox1 inhibition, attenuated LPS-induced …
microvascular remodeling in the developing lung. The mechanisms by which bacterial cell
wall components such as LPS mediate Ang2 signaling in human pulmonary microvascular
endothelial cells (HPMECs) remain understudied. In HPMEC, LPS-induced Ang2, Tie2, and
VEGF-A protein expression was preceded by increased superoxide formation. NADPH
oxidase 2 (Nox2) inhibition, but not Nox4 or Nox1 inhibition, attenuated LPS-induced …