An endothelial microRNA-1–regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis
A Korde, F Ahangari, M Haslip, X Zhang, Q Liu… - Journal of Allergy and …, 2020 - Elsevier
Background Airway eosinophilia is a prominent feature of asthma and chronic rhinosinusitis
(CRS), and the endothelium plays a key role in eosinophil trafficking. To date, microRNA-1
(miR-1) is the only microRNA known to be regulated in the lung endothelium in asthma
models. Objective We sought to determine the role of endothelial miR-1 in allergic airway
inflammation. Methods We measured microRNA and mRNA expression using quantitative
RT-PCR. We used ovalbumin and house dust mite models of asthma. Endothelium-specific …
(CRS), and the endothelium plays a key role in eosinophil trafficking. To date, microRNA-1
(miR-1) is the only microRNA known to be regulated in the lung endothelium in asthma
models. Objective We sought to determine the role of endothelial miR-1 in allergic airway
inflammation. Methods We measured microRNA and mRNA expression using quantitative
RT-PCR. We used ovalbumin and house dust mite models of asthma. Endothelium-specific …