[HTML][HTML] A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa
K Kotarsky, KM Sitnik, H Stenstad, H Kotarsky… - Mucosal …, 2010 - Elsevier
Intestinal-derived chemokines have a central role in orchestrating immune cell influx into the
normal and inflamed intestine. Here, we identify the chemokine CCL6 as one of the most
abundant chemokines constitutively expressed by both murine small intestinal and colonic
epithelial cells. CCL6 protein localized to crypt epithelial cells, was detected in the gut lumen
and reached high concentrations at the mucosal surface. Its expression was further
enhanced in the small intestine following in vivo administration of LPS or after stimulation of …
normal and inflamed intestine. Here, we identify the chemokine CCL6 as one of the most
abundant chemokines constitutively expressed by both murine small intestinal and colonic
epithelial cells. CCL6 protein localized to crypt epithelial cells, was detected in the gut lumen
and reached high concentrations at the mucosal surface. Its expression was further
enhanced in the small intestine following in vivo administration of LPS or after stimulation of …
