Association of a novel diagnostic biomarker, the plasma cardiac bridging integrator 1 score, with heart failure with preserved ejection fraction and cardiovascular …
AP Nikolova, TC Hitzeman, R Baum… - JAMA …, 2018 - jamanetwork.com
Importance Transverse tubule remodeling is a hallmark of heart failure. Cardiac bridging
integrator 1 (cBIN1) is a circulating membrane scaffolding protein that is essential for
transverse tubule health, and its plasma level declines with disease. Objective To determine
if a cBIN1-derived score can serve as a diagnostic biomarker of heart failure with preserved
ejection fraction (HFpEF). Design, Setting, and Participants In this cohort study, the cBIN1
score (CS) was determined from enzyme-linked immunoabsorbent assay–measured plasma …
integrator 1 (cBIN1) is a circulating membrane scaffolding protein that is essential for
transverse tubule health, and its plasma level declines with disease. Objective To determine
if a cBIN1-derived score can serve as a diagnostic biomarker of heart failure with preserved
ejection fraction (HFpEF). Design, Setting, and Participants In this cohort study, the cBIN1
score (CS) was determined from enzyme-linked immunoabsorbent assay–measured plasma …
