Immunological strategies to target HIV persistence

G Martrus, M Altfeld - Current Opinion in HIV and AIDS, 2016 - journals.lww.com
G Martrus, M Altfeld
Current Opinion in HIV and AIDS, 2016journals.lww.com
The better understanding of virus-specific immunity and the pathways used by HIV-1 to
evade host immune responses have enabled the development of new strategies focusing on
targeting latently HIV-1-infected cells, with the goal to reduce the HIV-1 reservoir. Here, we
will review recent advances in harnessing effector cells of the immune system, including
CD8+ T cells and natural killer cells, antiviral antibodies and new immunomodulatory
molecules, to target HIV-1 persistence.
Summary
The better understanding of virus-specific immunity and the pathways used by HIV-1 to evade host immune responses have enabled the development of new strategies focusing on targeting latently HIV-1-infected cells, with the goal to reduce the HIV-1 reservoir. Here, we will review recent advances in harnessing effector cells of the immune system, including CD8+ T cells and natural killer cells, antiviral antibodies and new immunomodulatory molecules, to target HIV-1 persistence.
Lippincott Williams & Wilkins