Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and …
P Wang, P Wu, KM Ohleth, RW Egan, MM Billah - Molecular pharmacology, 1999 - Elsevier
ABSTRACT The type 4 phosphodiesterase (PDE4) is the predominant PDE isozyme in
various leukocytes and plays a key role in the regulation of inflammatory cell activation.
There are four PDE4 subtypes (A, B, C, and D), and within each subtype, there are multiple
variants. Very recently, we found in monocytes that PDE4B gene expression is selectively
induced by lipopolysaccharide (LPS) and that the induction is inhibited by interleukin (IL)-10
and IL-4. In this study, we show that the PDE4B gene is constitutively expressed in …
various leukocytes and plays a key role in the regulation of inflammatory cell activation.
There are four PDE4 subtypes (A, B, C, and D), and within each subtype, there are multiple
variants. Very recently, we found in monocytes that PDE4B gene expression is selectively
induced by lipopolysaccharide (LPS) and that the induction is inhibited by interleukin (IL)-10
and IL-4. In this study, we show that the PDE4B gene is constitutively expressed in …
