In this study, an innovative bioavailable gingerol formulation, Ginactiv, was prepared by using polar–nonpolar sandwich (PNS) technology with a full spectrum of ginger matrix (FSGM). SEM images showed that Ginactiv was almost spherical, was well dispersed, had a smooth morphology with a particle size range of 50–60 μm, and was divided by three layers of PNS formulation. IR, DSC, a stability study, an enhanced and sustained release profile, and the good antioxidant potential of Ginactiv furthermore confirmed the existence of gingerols with great stability in a bioavailable form in the PNS formulation. Ginactiv registered a higher moisture content (3.98 ± 1.17%), hygroscopicity (0.94 ± 0.23 g/g), and water solubility index (43.71 ± 3.42%) in comparison to the ginger oleoresin values of 1.96 ± 0.72%, 0.36 ± 0.13 g/g, and 9.62 ± 1.21%, respectively, due to the good encapsulation of gingerols by the PNS technology. The existence of the synergistic effects of FSGM in Ginactiv can be utilized as a natural dietary supplement for supporting gastrointestinal and gut health improvement and to maintain the gut–brain axis.