Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients

R Cervera, MA Khamashta, J Font, GD Sebastiani… - Medicine, 2003 - journals.lww.com
In the present study, we assessed the frequency and characteristics of the main causes of
morbidity and mortality in systemic lupus erythematosus (SLE) during a 10-year period and
compared the frequency of early manifestations with those that appeared later in the
evolution of the disease. In 1990, we started a multicenter study of 1,000 patients from 7
European countries. All had medical histories documented and underwent medical interview
and routine general physical examination when entered in the study, and all were followed …