A conserved pathway that controls c-Myc protein stability through opposing phosphorylation events occurs in yeast
JR Escamilla-Powers, RC Sears - Journal of Biological Chemistry, 2007 - jbc.org
The c-Myc transcription factor is a key regulator of cell proliferation and cell fate decisions. c-
Myc overexpression is observed in a variety of human tumors, revealing the importance of
maintaining normal levels of c-Myc protein. c-Myc protein stability in mammalian cells is
controlled by interdependent and sequential phosphorylation and dephosphorylation events
on two highly conserved residues, serine 62 and threonine 58. Here we show that these
sequential phosphorylation and dephosphorylation events and their effect on c-Myc stability …
Myc overexpression is observed in a variety of human tumors, revealing the importance of
maintaining normal levels of c-Myc protein. c-Myc protein stability in mammalian cells is
controlled by interdependent and sequential phosphorylation and dephosphorylation events
on two highly conserved residues, serine 62 and threonine 58. Here we show that these
sequential phosphorylation and dephosphorylation events and their effect on c-Myc stability …
