Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: the role of thymic stromal lymphopoietin
Background Type 2 innate lymphoid cells (ILC2s) represent an important type 2 immune
cell. Glucocorticoid regulation of human ILC2s is largely unknown. Objective We sought to
assess steroid resistance of human blood and airway ILC2s from asthmatic patients and to
examine its mechanism of induction. Methods We studied human blood and lung ILC2s from
asthmatic patients and control subjects using flow cytometry and ELISA. Results
Dexamethasone inhibited (P=. 04) chemoattractant receptor–homologous molecule …
cell. Glucocorticoid regulation of human ILC2s is largely unknown. Objective We sought to
assess steroid resistance of human blood and airway ILC2s from asthmatic patients and to
examine its mechanism of induction. Methods We studied human blood and lung ILC2s from
asthmatic patients and control subjects using flow cytometry and ELISA. Results
Dexamethasone inhibited (P=. 04) chemoattractant receptor–homologous molecule …
