Discovery of 2, 3, 5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
Z Zhao, WH Leister, RG Robinson, SF Barnett… - Bioorganic & medicinal …, 2005 - Elsevier
Z Zhao, WH Leister, RG Robinson, SF Barnett, D Defeo-Jones, RE Jones, GD Hartman…
Bioorganic & medicinal chemistry letters, 2005•ElsevierDiscovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors -
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Bioorganic & Medicinal Chemistry Letters Volume 15, Issue 4, 15 February 2005, Pages 905-909
Bioorganic & Medicinal Chemistry Letters Discovery of 2,3,5-trisubstituted pyridine
derivatives as potent Akt1 and Akt2 dual inhibitors Author links open overlay panel Zhijian …
ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books Help
Search My account Sign in View PDF Download full issue Search ScienceDirect Elsevier
Bioorganic & Medicinal Chemistry Letters Volume 15, Issue 4, 15 February 2005, Pages 905-909
Bioorganic & Medicinal Chemistry Letters Discovery of 2,3,5-trisubstituted pyridine
derivatives as potent Akt1 and Akt2 dual inhibitors Author links open overlay panel Zhijian …
This letter describes the discovery of a novel series of dual Akt1/Akt2 kinase inhibitors, based on a 2,3,5-trisubstituted pyridine scaffold. Compounds from this series, which contain a 5-tetrazolyl moiety, exhibit more potent inhibition of Akt2 than Akt1.
Elsevier
