Optimal human pathogenic TH2 cell effector function requires local epithelial cytokine signaling
J Calise, N Garabatos, V Bajzik, M Farrington… - Journal of Allergy and …, 2021 - Elsevier
Background IL-33 is an emerging key factor in development of allergic diseases. The IL-33
receptor (suppressor of tumorigenicity [ST2]) is a differentially expressed gene in pathogenic
TH 2 cells, but its role in T-cell effector function has not been elucidated. Objective We
investigated the role of IL-33 in modulating circulating allergen-specific T-cell responses. We
hypothesized that selective ST2 expression on allergen-specific CD4+ T cells would confer
susceptibility to the effects of IL-33. Methods PBMCs from subjects with food allergy, inhalant …
receptor (suppressor of tumorigenicity [ST2]) is a differentially expressed gene in pathogenic
TH 2 cells, but its role in T-cell effector function has not been elucidated. Objective We
investigated the role of IL-33 in modulating circulating allergen-specific T-cell responses. We
hypothesized that selective ST2 expression on allergen-specific CD4+ T cells would confer
susceptibility to the effects of IL-33. Methods PBMCs from subjects with food allergy, inhalant …
