Factors associated with serological response to SARS-CoV-2 vaccination in patients with multiple sclerosis treated with rituximab

A Tolf, A Wiberg, M Müller, FH Nazir… - JAMA network …, 2022 - jamanetwork.com
Importance B-cell–depleting monoclonal antibodies are widely used for treatment of multiple
sclerosis but are associated with an impaired response to vaccines. Objective To identify
factors associated with a favorable vaccine response to tozinameran. Design, Setting, and
Participants This prospective cohort study was conducted in a specialized multiple sclerosis
clinic at a university hospital from January 21 to December 1, 2021. Of 75 patients evaluated
for participation who received a diagnosis of multiple sclerosis with planned or ongoing …