Association between immune dysfunction and COVID-19 breakthrough infection after SARS-CoV-2 vaccination in the US
Importance Persons with immune dysfunction have a higher risk for severe COVID-19
outcomes. However, these patients were largely excluded from SARS-CoV-2 vaccine
clinical trials, creating a large evidence gap. Objective To identify the incidence rate and
incidence rate ratio (IRR) for COVID-19 breakthrough infection after SARS-CoV-2
vaccination among persons with or without immune dysfunction. Design, Setting, and
Participants This retrospective cohort study analyzed data from the National COVID Cohort …
outcomes. However, these patients were largely excluded from SARS-CoV-2 vaccine
clinical trials, creating a large evidence gap. Objective To identify the incidence rate and
incidence rate ratio (IRR) for COVID-19 breakthrough infection after SARS-CoV-2
vaccination among persons with or without immune dysfunction. Design, Setting, and
Participants This retrospective cohort study analyzed data from the National COVID Cohort …
