Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction
Recent studies suggest that the fly uses the inositol lipid signaling system for visual
excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this
process subsequent to the production of IP3. In this paper, we show that frp encodes a novel
1275 amino acid protein with eight putative transmembrane segments. lmmunolocalization
indicates that the frp protein is expressed predominantly in the rhabdomeric membranes of
the photoreceptor ceils.
excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this
process subsequent to the production of IP3. In this paper, we show that frp encodes a novel
1275 amino acid protein with eight putative transmembrane segments. lmmunolocalization
indicates that the frp protein is expressed predominantly in the rhabdomeric membranes of
the photoreceptor ceils.
Summary
Recent studies suggest that the fly uses the inositol lipid signaling system for visual excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this process subsequent to the production of IP3. In this paper, we show that frp encodes a novel 1275 amino acid protein with eight putative transmembrane segments. lmmunolocalization indicates that the frp protein is expressed predominantly in the rhabdomeric membranes of the photoreceptor ceils.
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