The diffusible messenger NO plays multiple roles in neuroprotection, neurodegeneration,
and brain plasticity. Argininosuccinate synthase (AS) is a ubiquitous enzyme in mammals
and the key enzyme of the NO-citrulline cycle, because it provides the substrate l-arginine
for subsequent NO synthesis by inducible, endothelial, and neuronal NO synthase (NOS).
Here, we provide evidence for the participation of AS and of the NO-citrulline cycle in the
progress of differentiation of neural stem cells (NSC) into neurons, astrocytes, and …