The vascular endothelium plays a critical role in vascular homeostasis. Inflammatory
cytokines and non-laminar blood flow induce endothelial dysfunction and confer a pro-
adhesive and pro-thrombotic phenotype. Therefore, identification of factors that mediate the
effects of these stimuli on endothelial function is of considerable interest. Kruppel-like factor
4 expression has been documented in endothelial cells, but a function has not been
described. In this communication we describe the expression in vitro and in vivo of Kruppel …