Therapeutic targeting of chemokine signaling in Multiple Sclerosis

I Hamann, F Zipp, C Infante-Duarte - Journal of the neurological sciences, 2008 - Elsevier
Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that
is initiated and maintained by continuous migration of inflammatory immune cells from the
periphery into the target organ. However, in autoimmunity, migration of immune cells is not
only involved in the pathogenesis but also in the down-modulation of the autoimmune
attack, which is probably mediated by the infiltration of certain regulatory immune cell
populations inside the affected organs. The migratory activity of both proinflammatory and …