Mitochondrial dysfunction in airway disease

YS Prakash, CM Pabelick, GC Sieck - Chest, 2017 - Elsevier
There is increasing appreciation that mitochondria serve cellular functions beyond oxygen
sensing and energy production. Accordingly, it has become important to explore
noncanonical roles of mitochondria in normal and pathophysiological processes that
influence airway structure and function in the context of diseases such as asthma and
COPD. Mitochondria can sense upstream processes such as inflammation, infection,
tobacco smoke, and environmental insults important in these diseases and in turn can …