[HTML][HTML] Uric acid pathway activation during respiratory virus infection promotes Th2 immune response via innate cytokine production and ILC2 accumulation
Respiratory syncytial virus (RSV) infects a majority of infants and can cause severe disease
leading to increased risk to develop asthma later in life. In the present studies we detected
high levels of uric acid pathway components during RSV infection and examined whether
they altered the pathogenesis of RSV infection. Inhibition of uric acid (UA) pathway
activation during RSV infection in airway epithelial cells using XOI decreased the expression
of IL-33, thymic stromal lymphopoietin (TSLP), and CCL2. In addition, treatment of RSV …
leading to increased risk to develop asthma later in life. In the present studies we detected
high levels of uric acid pathway components during RSV infection and examined whether
they altered the pathogenesis of RSV infection. Inhibition of uric acid (UA) pathway
activation during RSV infection in airway epithelial cells using XOI decreased the expression
of IL-33, thymic stromal lymphopoietin (TSLP), and CCL2. In addition, treatment of RSV …